The ADA Council on Scientific Affairs states: “Fluoride varnish applied every six months is effective in preventing caries in the primary and permanent dentition of children and adolescents.” They further state that Fluoride varnish creates less patient discomfort and achieves greater patient acceptance than fluoride gel, especially in preschool-aged children. Two or more applications of fluoride varnish per year are effective at preventing caries in high-risk populations.